Though the Miscellaneous Manuscripts collection is composed of items that do not fall readily into any other existing collection, the two dominant intellectual areas represented in the collection are Early American History and History of Science.

This online guide brings together photographs, engravings, lithographs, and paintings from a legacy APS collection known as the Prints and Photographs collection. The guide was created to provide online access to descriptive information for prints and photographs that were not associated with manuscripts collections. Some of these items are also described in the APS online public access catalog for printed materials. An in-house Print Collection card file arranged by name and subject provides item-level access to some of the items below and additional prints and photographs that do not yet have online descriptions. Former designations for these included the following: Persons, Places and things, Group pictures, Collections (manuscripts); Oversize--Persons, Oversize--Places and things, and Oversize--Collections (manuscripts). When researching at the library, please consult with reference staff to locate these items.

The collection of Charles Coleman Sellers (1903-1980) contains copious and detailed documentation of the art of Charles Willson Peale and his family. It consists of working files for Sellers's numerous publications, including his Portraits and Miniatures by Charles Willson Peale (1952); Charles Willson Peale with Patron and Populace (1969); C. W. Peale's Portraits of Washington (1951); Benjamin Franklin in Portraiture (1962); Mr. Peale's Museum (1980). Most files include photographs of the art work, notes on the piece, and correspondence with authorities or owners. Other series include one relating to the paintings of various other Peales, including Anna C., James, Mary Jane, Raphaelle, Rembrandt, Rubens, and Sarah Miriam, and a miscellaneous artist file, which includes the same type of material and information on many eighteenth- and nineteenth-century artists, including Thomas Eakins, George Healy, Robert Edge Pine, William Rush, Thomas Sully, Benjamin West, James Abbott McNeill Whistler, etc. There is a separate Sellers collection at Dickinson College, primarily personal in nature.

Simon Flexner, born in 1863, one of the nation's leading experts in pathology and bacteriology, was most renowned for his research on cerebrospinal meningitis, polio and infantile paralysis. Arguably though, Flexner's stewardship of the Rockefeller Institute was his greatest contribution to medical and scientific research. His rise in the medical community began in the late nineteenth century in Louisville, Kentucky, where despite not having completed even the seventh grade, Flexner taught himself basic bacteriology by conducting experiments at home using a microscope borrowed from the pharmacy where he served as an apprentice. Granted a medical degree from the University of Louisville School of Medicine in 1889, he went on to a pathology fellowship at the newly opened John Hopkins School of Medicine. Within two short years of leaving Louisville, Flexner received an assistant of pathology appointment at Johns Hopkins. It was a quick ascent and the beginning of a long and brilliant career that included a prestigious appointment at the University of Pennsylvania and then a directorship at the new Rockefeller Institute where he realized his lifelong dream of creating a dynamic and productive research laboratory. The Rockefeller Institute became instantly famous worldwide as the preeminent research facility for virology and under Flexner's direction produced invaluable contributions in pathology, bacteriology, and immunology. This collection does not reflect the early phases of Flexner's career at Johns Hopkins but does document an early interest in meningitis and other infectious diseases with science-related correspondence, laboratory notebooks, and administrative correspondence with the New York City and State Departments of Health. There is abundant material on Flexner's directorship of the Rockefeller Institute for Medical Research, including Flexner's search for staff, an involved process which is detailed in correspondence with the scientists, many of whom became quite famous. Also included is material relating to the other institutions and Rockefeller philanthropies with which Flexner was involved. (Among the most significant correspondence, however, may be that which documents the support of the General Education Board and the Rockefeller Foundation in the development and subsequent reorganization of medical schools following brother Abraham Flexner's scathing report on medical education in the United States and Canada). This collection would be of great interest to anyone interested in the history of bacteriology, histology, and immunology or the general history of modern medicine and philanthropy.

Frank Siebert (1913-1998) is one of the key contributors to the field of Algonquian linguistics. While he did not pursue a degree in linguistics or anthropology, he independently acquired the skills and knowledge of a professional scholar. His work on Penobscot is some of the best and most comprehensive in existence. The Siebert Papers document the interest and work of Frank Siebert in the linguistics of the Algonquian family of languages, particularly Penobscot. The collection includes correspondence, research notes, drafts and published manuscripts by Siebert, as well as secondary sources consulted by Siebert. To a lesser extent, it contains material that documents Siebert's personal life, his interest in book collecting and his career as a physician.

An archaeological anthropologist and linguist, John Alden Mason spent the majority of his career at the University Museum of the University of Pennsylvania. After receiving his undergraduate degree at Penn in 1907, Mason received a doctorate at Berkeley (1911) for his ethnographic work on the Salinan Indians of California, but his diverse interests in later years ran the gamut from Puerto Rican folklore to Piman languages and cultures (including Pima, Papago, Pima Bajo, Northern and Southern Tepehuan, and Tepecano), Mayan, Aztec, and Incan archaeology, and the languages of South American Indians. Mason was curator of the University Museum at Penn from 1926 until his retirement in 1958. The Mason Papers include both in-coming and outgoing correspondence, linguistic material, notes, and photographs relating to Mason's work in the southwestern U.S., northern Mexico, and South America. Centered on the years after Mason's return to Philadelphia in 1926, the collection covers all aspects of Mason's professional life, from reports on field work to answering casual questions referred to him through the University Museum to data and analyses on Piman and other languages. The collection also contains voluminous files relating to the Mason's editorship of the American Anthropologist (bulk: 1945-1948). Of special note are a series of class notes (1908-1910) kept by Mason for course work in ethnology, archaeology, and linguistics at the University of Pennsylvania under Edward Sapir and Frank Speck.

The Mary Rosamond Haas papers are extensive, including correspondence, research notes, field notes, texts, lexical slip files, audio recordings, photographs, reprints and more, covering more than 100 languages of North America and Southeast Asia. Of particular value are notes and audio recordings from fieldwork from the 1930s on Ditidaht, Tunica, Natchez and Muscogee, work toward pedagogical materials for Thai, and groundbreaking comparative studies of several language families of North America.

Anthropologist and ethnographer Frank Gouldsmith Speck was one of Franz Boas' early graduate students and from 1907 till his death in 1950 spent his career in a variety of positions at the University of Pennsylvania, including its Museum of Archaeology and Anthropology. Unlike most of his contemporaries, Speck chose to study the cultures of Indigenous peoples of eastern North America, especially the Haudenosaunee, Cherokee, and peoples speaking Algonquian languages, such as Anishinaabe, Wabanaki, Innu, Lenape, and other Algonquian peoples within the eastern United States. Speck spent a larger amounnt of time in the field than was typical of most ethnographers, collecting documentary information and physical objects. The Frank G. Speck Papers consist of 15.5 linear feet of Speck's professional correspondence, field notes, lecture notes, and manuscripts of published and unpublished works. The material focuses on the Eastern Woodlands Indians, particularly the Catawba, Cherokee, Creek, Delaware, Houma, Haudenosaunee ("Iroquois"), Labrador Inuit ("Eskimo"), Innu ("Montagnais-Naskapi"), Nanticoke, Penobscot, Powhatan, Algonquian, and Yuchi. The collection is divided into two subcollections: Subcollection 1 is comprised of Speck's research material and correspondence, and Subcollection 2 consists of his manuscripts and related correspondence. The two subcollections were acquired separately by the Society, and were originally cataloged as the Frank G. Speck Papers (572.97 Sp3) and the Frank G. Speck Manuscripts on Native Americans (970.3 Sp3p) respectively.